Professor Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays that influence the way CML patients are managed world-wide. He has given 42 keynote talks at international meetings since 2009. He has published 250+ papers with 18,000+ citations. He Co-founded the International CML Foundation in 2008 and was elected Chair in 2014.