Professor Susan Clark is a worldwide pioneer in the field of cancer epigenetics. Her research revolutionised the field through her pivotal contribution to advancements in new technologies for profiling DNA methylation changes in early development and cancer. Her current research involves understanding the 3D epigenetic landscape of large‐scale domains in cancer, and developing new genome‐wide sequencing and bioinformatic protocols to map DNA methylation, histone modifications and regulatory RNA profiles.
Professor Clark’s team has recently demonstrated that epigenetic changes in cancer encompass large genome‐wide domains, resulting in global and coordinated gene silencing and activation, which provide new insights for disease diagnosis and treatments.