Simon Gandevia is a clinical neurophysiologist with a history of major discoveries about human movement control in health and disease. His research covers three strands: (i) neural mechanisms of proprioception; (ii) neural control of muscle performance, especially during muscle fatigue; and (iii) control of human breathing muscles. His work has provided insight into many disorders, including stroke, spinal cord injury, prior–‐polio, asthma, chronic obstructive pulmonary disease, and obstructive sleep apnoea. Also, he was a founder of the Prince of Wales Medical Research Institute (now NeuRA) in 1992 and elected a Fellow of the Australian Academy of Science in 1998.