Professor Philip Hogg

Professor Philip Hogg

FAHMS

Director, ACRF-Centenary Cancer Research Centre
The Centenary Institute
Fellow
Elected in 2017
NSW
Citation on election

Phil Hogg discovered a unique mechanism of control of protein function that operates across all biological systems and lifeforms. This involves a subset of disulphide bonds thought only to act as covalent modifiers of protein structure functioning as molecular switches to allosterically regulate protein function when cleaved. He developed a novel classification scheme for disulphides and uncovered a conformational signature for the allosteric bonds that underpins their facile nature. He has shown that thrombosis as well as immune responses and viral infections are critically regulated by this previously unrecognised chemical modification.

 

 

Find out more

Whether you’re looking to nominate a colleague for an award, make a donation to the Academy or simply find out more about the work we do, research we advance and health policy advice we provide, sign up to our mailing list today.

Keep up to date with the latest news

By providing your email address, you consent to it being added to our mailing list.