Patrick Tam is a world leader in the study of mammalian development and his scientific achievement has put Australia on the global map of developmental biology. He pioneered the application of experimental embryology and genome editing to elucidate the cellular and molecular architecture of the basic body plan. His work has contributed to the construction of detailed fate maps for the embryo and the understanding of pathogenic mechanism of birth defects. He has a prominent leadership role through advisory, consultative and editorial activities. Patrick is a fellow of Australian Academy of Science, Royal Society of Biology, and Royal Society of London.