Professor Moseley has made seminal contributions to our understanding of persistent pain disorders and the role of brain processes in etiology and in treatment. He pioneered intensive pain biology education (‘Explaining pain’) as a treatment for chronic pain, which generated a new field of research and clinical practice. He also developed a specific treatment, which targets disrupted brain processes in chronic pain, that is now recommended in clinical guidelines internationally and considered best practice. His discoveries of cognitive influences over bodily effects have generated new lines of research. His contributions have been recognised by awards and honours on every continent.