Professor Jurgen Götz

Professor Jurgen Götz

FAHMS

Foundation Chair of Dementia Research, Director, Clem Jones Centre for Ageing Dementia Research
Queensland Brain Institute, The University of Queensland
Fellow
Elected in 2016
QLD
Citation on election

Alzheimer’s Disease is characterized by amyloid plaques and tau tangles. Understanding their role in pathology is crucial for developing a treatment for this yet incurable disease.  Professor Jürgen Götz generated the first transgenic mouse model with a tau pathology.  By combining a transgenic with a transplantation approach he proved the amyloid cascade hypothesis, a concept central in the field, and showed that amyloid induces a tau pathology.  He also demonstrated that tau is needed for amyloid to exert toxicity, by ‘axonal’ tau assuming a previously unidentified function in dendrites.  He developed a novel scanning ultrasound approach to reduce amyloid toxicity.

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