Professor John Miners

Professor John Miners has made sustained contributions to the characterisation of the enzymatic basis of drug metabolism, which underpins the individualisation of drug therapy in humans. His research has: identified sources of variability in drug metabolism, especially drug-drug interactions and pharmacogenetics; characterised the substrate and inhibitor selectivities and structure-function relationships of the key drug metabolising enzymes cytochrome P450 and UDP-glucuronosyltransferase; and developed in vitro experimental paradigms that predict drug metabolism and disposition parameters in humans. The research has played a pivotal role in establishing drug metabolism as a predictive science that supports preclinical drug development and the clinical use of drugs.