Professor Jamie Cooper has demonstrated outstanding leadership while managing an expansive portfolio of research in intensive care medicine and mentoring the next generation of clinician-scientists. In his multi-faceted career at Monash University and The Alfred, Professor Cooper has played significant leadership roles as clinician, researcher, educator and mentor. Under his leadership, the ANZIC Research Centre at Monash University has earned an international reputation for training critical care specialists in the methodology and execution of world-class research and multi-centre trials. His research has challenged prevailing dogmas and led to improved patient outcomes and major financial savings to the Australian healthcare system.