Henry Burger is a clinician-scientist who has made major contributions to general and reproductive endocrinology. He was a co-leader of the group which successfully isolated inhibin. He showed that it had an important clinical role in the diagnosis and monitoring of ovarian malignancy. He defined the role of inhibin in the endocrinology of the menopausal transition and menopause. For more than 30 years, he has been a leader in menopause management, particularly in promoting the efficacy and safety of postmenopausal hormone therapy. He has received numerous international and national awards and has published more than 600 papers.