Throughout a 35-year career in medical research, Professor Mann has made key contributions to knowledge of human health, many of which have changed practice, and he is recognised internationally as a leader in basic and translational research in melanoma. He has led or jointly driven major projects, partnerships and collaborations that have made melanoma research an exemplar of unquestioned leadership for Australia, as well as of effective international cooperation in research. Furthermore he has consistently supported and promoted strategic development of health and medical research at institutional, state and national levels.