Colin Masters’ work over the last 35 years is widely acknowledged as having had a major influence on Alzheimer’s disease research world-wide, particularly the collaborative studies conducted with Konrad Beyreuther in which they discovered the proteolytic neuronal origin of the Aβ amyloid protein which causes Alzheimer’s disease. Masters has continued to identify and develop effective rational therapeutic and diagnostic strategies for disease modification, perhaps even prevention. Masters’ publishes on average 30 papers a year, serves on 19 Editorial Boards, is an advisory member of 17 research organizations and continues to lecture widely, both nationally and internationally.