As a clinician scientist, understanding the genetic basis of cardiovascular disease has been the cornerstone of my research endeavours. Using an integrated translational approach in human families, murine models, and cell culture systems, my research has elucidated the genetic causes of cardiomyopathies and sudden death, identified key signalling pathways involved in development of disease, and provided a platform for this knowledge to be directly translated to cardiovascular medicine by improved diagnostic and risk stratification strategies. My research has led to the reduction of both mortality and morbidity amongst individuals and families with genetic heart disease.
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