Professor Arthur Christopoulos
“Discovery and dissemination of the concept of allosteric sites on receptor proteins as a novel avenue for drug discovery”. Professor Christopoulos has demonstrated how this approach can be used to identify, validate, quantify, and facilitate preclinical translation of small molecules with an allosteric mode of action for all classes of G protein-coupled receptor (GPCR), the […]
Professor John Christodoulou
John Christodoulou is clinical geneticist working in the management of children with inborn errors of metabolism for over 25 years. He has a longstanding interest in Rett syndrome (RTT), with a potential new therapy and the discovery the second gene associated with RTT as notable achievements. More recently, using next generation sequencing (NGS) he identified […]
Professor Sherene Loi
Professor Sherene Loi has made significant contributions in breast cancer research. These include 1. understanding the role of the immune system and its reaction to breast cancers, 2. how doctors can therapeutically and potentially favourably alter the immune response, 3. development of important new drugs for breast cancer patients including palbocicilb and pertuzumab which have […]
Professor Jamie Rossjohn
Rossjohn has provided profound insight into T-cell biology, defining the basis of key immune recognition events by T-cells. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR recognises polymorphic Human Leukocyte Antigen (HLA) molecules. He has unearthed mechanisms of HLA polymorphism impacting on drug and food […]
Professor Mark Dawson
As a clinician-scientist, Professor Dawson has consistently demonstrated academic excellence and leadership both in basic science discoveries and the translation of these findings into the clinical arena. His research into chromatin regulation of normal and malignant haematopoiesis have provided a range of groundbreaking discoveries including the development in collaboration with GSK of the first clinical therapies […]
Professor Graeme Young
Professor Graeme Young AM is a global leader in prevention of colorectal cancer. His contributions span epithelial and molecular biology, nutrition, biomarker development and validation, clinical and population randomised trials. He established the Flinders Centre for Innovation in Cancer as Director of Development and chaired the growth of the most influential global network in colorectal […]