Professor Eisman’s major contributions include the first clinical assay of active vitamin D, importance of vitamin D in cancer, then strong genetic determination of bone mass, identification of the first candidate gene and role in international osteoporosis GWAS. He demonstrated the importance of all fragility fractures in men and women, their relationship to premature death and treatment benefit on survival. He has established international consortia for better translation to health care. Recently he was awarded the senior, William F Neuman award of the American Society for Bone and Mineral Research and is President-elect of the International Bone and Mineral Society.