Professor John Chalmers was admitted to the Australian Academy of Science (1987) for his studies elucidating the neurotransmitters and brain pathways involved in baroreflex control of blood pressure and contributing to experimental hypertension. He chaired the guidelines committee of the WHO and the International Society of Hypertension(1988-2000). He helped found the George Institute for Global Health and has initiated and chaired four major international clinical trials of blood pressure lowering in patients with stroke or diabetes-the PROGRESS, ADVANCE, INTERACT and ENCHANTED trials, the first three of which have had a major impact on clinical practice, while the 4th is ongoing.