Professor Sherene Loi has made significant contributions in breast cancer research. These include 1. understanding the role of the immune system and its reaction to breast cancers, 2. how doctors can therapeutically and potentially favourably alter the immune response, 3. development of important new drugs for breast cancer patients including palbocicilb and pertuzumab which have both improved outcomes for breast cancer patients and 4. incorporation of genomic sequencing into clinical care of advanced breast cancer patients to help guide therapy choices. She is an international leader in breast cancer translational research, is widely cited and has over 110 peer-reviewed publications.