Professor Ego Seeman is recognised as a global leader in the field of bone health through a series of studies that have transformed our understanding of the pathogenesis and treatment of osteoporosis. His pioneering studies on bone growth in utero, and delineation of sex and racial differences in bone architecture during growth help explain the sex and racial differences in fractures in adulthood. His work in cortical and trabecular microstructural deterioration as a cause of bone fragility has provided important insights into bone fragility. He is among the top 10 most-cited investigators in the bone field worldwide.