After establishing a world-first clinical exercise physiology service in a cardiac transplant unit, Professor Daniel Green’s research provided a compelling evidence-base for disease prevention by quantifying the mechanisms and benefits of novel interventions to prevent and manage cardiovascular (CV) diseases. Central to his discoveries was development of novel imaging techniques, now used worldwide, that directly quantify CV function. To translate his knowledge gains, he pioneered new allied health professions (Clinical Exercise Physiology) in Australia and the UK, resulting in national practitioner registries, proficiency standards and curriculum frameworks. He has directly impacted health service provision and higher education platforms globally.