Professor Sinclair’s groundbreaking research, including the discovery of the Y-linked SRY (testis) gene, underpin our understanding of normal and dysfunctional gonad development and its impact on children with Disorders of Sex Development. Importantly, he has translated his work into the clinic by developing much-needed rapid and accurate diagnostic tests. His research excellence, along with his prominent role in research translation, exemplary service to medical genetics community and more broadly as President of the Australian Society for Medical Research and member of the NHMRC Human Genetics Advisory Committee makes Professor Sinclair an outstanding candidate for election to the Academy.